반응 #417929

반응 방정식

water

6,6-Dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-ol

pyridine

pivaloylchloride

→

colourless crystals

수율 15.7%

2,2-Dimethyl-propionic acid 6,6-dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-yl ester

수율 15.7%

용매

ethylacetate cyclohexane

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타the organic phase separated
3. 3
   농축concentrated

실험 절차

To a solution of 6,6-Dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-ol (1.92 g, 5.61 mmol) prepared according to the above Example 1 in methylenehloride (70 ml) was added at 0° C. pyridine (1.77 g, 22.4 mmol), followed by pivaloylchloride (0.744 g, 6.17 mmol). After stirring at room temperature for 16 h methylenehloride and water was added, the organic phase separated and concentrated. Chromatography over silica with ethylacetate/cyclohexane gave 380 mg colourless crystals (0.88 mmol).

출처