반응 #417927

반응 방정식

ethylacetate cyclohexane

thioacetic acid S-(2-trifluoromethyl-benzyl)ester

methanol

3-Bromomethyl-pyridine-2-carboxylic acid methyl ester

→

colorless crystals

수율 100.0%

3-(2-Trifluoromethyl-benzylsulfanylmethyl)-pyridine-2-carboxylic acid methyl ester

수율 100.0%

용매

water

반응 조건

후처리

1. 1
   온도after refluxing for 150 min the solution
2. 2
   추출extracted with ethylacetate
3. 3
   건조the organic phase dried with sodium sulfate
4. 4
   농축concentrated

실험 절차

To a solution of thioacetic acid S-(2-trifluoromethyl-benzyl)ester (10.2 g, 37.5 mmol) in methanol (130 ml) potassium carbonate (5.18 g, 37.5 mmol) was added at room temperature and it was stirred for 30 min. 3-Bromomethyl-pyridine-2-carboxylic acid methyl ester (4.40 g, 18.7 mmol) was added and after refluxing for 150 min the solution was diluted with water, extracted with ethylacetate, the organic phase dried with sodium sulfate and concentrated. Chromatography over silica with ethylacetate/cyclohexane gave 7.82 g colorless crystals (18.7 mmol).

출처