반응 #417925

반응 방정식

32

methyl 4-hydroxybenzoate

K2CO3

13

1-iodoundec-4Z-ene

→

yellow oil

수율 100.1%

methyl 4-(undec-4Z-enyloxy)benzoate

수율 100.1%

용매

DMF

반응 조건

후처리

1. 1
   기타After reaction for 7 hours at 90° C.
2. 2
   농축the reaction medium is concentrated
3. 3
   세척washed with water

실험 절차

90 mg of 32 (590 μmol) and 81 mg of K2CO3 (590 μmol) are added to 150 mg of 13 (535 μmol) in anhydrous DMF (2 mL). After reaction for 7 hours at 90° C., the reaction medium is concentrated, taken up in DCM and then washed with water. 163 mg of a yellow oil are obtained, and are chromatographed on silica gel in pentane/ethyl acetate (80/1). 129 mg of the expected coupling product are isolated in the form of a yellow oil, i.e. a yield of 79%.

출처