반응 #417917
ord-22aaffe062774d3e82cefa2a869d2bda
반응 방정식
(S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine
naphthalene
→
(3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.