반응 #41791

반응 방정식

4-(4-methylamino-3-nitro-phenoxy)-pyridine-2-carboxylic acid (2-hydroxy-ethyl)-amide

→

product

4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid (2-hydroxy-ethyl)-amide

용매

methanol

반응 조건

후처리

1. 1
   기타flushed with nitrogen
2. 2
   기타Hydrogen was flushed through the reaction for 1-2 hours or until the reaction
3. 3
   기타Nitrogen was flushed through the reaction for 15 minutes before the reaction
4. 4
   여과was filtered through a celite pad
5. 5
   세척The celite pad was washed with excess methanol before it
6. 6
   기타all removed by evaporation under reduced pressure

실험 절차

A solution of 4-(4-methylamino-3-nitro-phenoxy)-pyridine-2-carboxylic acid (2-hydroxy-ethyl)-amide (1 eq) and 10% palladium on carbon (0.1 eq) in methanol was stirred at room temperature and flushed with nitrogen. Hydrogen was flushed through the reaction for 1-2 hours or until the reaction was determined to be complete by HPLC. Nitrogen was flushed through the reaction for 15 minutes before the reaction was filtered through a celite pad. The celite pad was washed with excess methanol before it was all removed by evaporation under reduced pressure to afford the product as a light yellow solid. LCMS m/z 303.2 (MH+), tR=1.5 min.

출처