반응 #41789

반응 방정식

6-Nitro-indole-1-carboxylic acid t-butyl ester

hydrogen

→

6-Amino-2,3-dihydro-indole-1-carboxylic acid t-butyl ester

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타resulting mixture
2. 2
   여과The reaction mixture was then filtered through celite and solvent
3. 3
   기타removed in vacuo

실험 절차

6-Nitro-indole-1-carboxylic acid t-butyl ester (1 eq) was dissolved in methanol (0.1M), to this solution was added palladium on carbon (0.1 eq) in methanol under nitrogen. A hydrogen atmosphere was then inserted and resulting mixture allowed to stir for 3 hours at room temperature. The reaction mixture was then filtered through celite and solvent removed in vacuo to afford 6-Amino-2,3-dihydro-indole-1-carboxylic acid t-butyl ester as a white solid. MS: MH+ 235

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