반응 #41782

반응 방정식

methyl iodide

methyl5-[3-amino-4-(methylamino)phenoxy]pyridine-3-carboxylate

4-bromophenylisothiocyanate

→

methyl5-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-3-carboxylate

용매

methanol

반응 조건

후처리

1. 1
   workup.STIRRINGstirred overnight at 60° C
2. 2
   온도The reaction was cooled down to room temperature
3. 3
   기타evaporated
4. 4
   세척washed with water and brine
5. 5
   기타dried
6. 6
   기타evaporated under reduced pressure

실험 절차

A solution of the methyl5-[3-amino-4-(methylamino)phenoxy]pyridine-3-carboxylate (1 eq) in methanol (8 ml) was treated with 4-bromophenylisothiocyanate (1 eq) and stirred at 60° C.-65° C. for 2 hours. The reaction mixture was cooled down to room temperature and methyl iodide (1 eq) was added and stirred overnight at 60° C. The reaction was cooled down to room temperature, evaporated, taken up in ethyl acetate and washed with water and brine, dried, evaporated under reduced pressure. Column chromatography yielded methyl5-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-3-carboxylate. MS: MH+=452

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