반응 #417709

반응 방정식

ethylene glycol

p-toluene sulfonic acid

→

cetal

용매

benzene

반응 조건

후처리

1. 1
   기타The synthesis of starting materials (1)-(3)
2. 2
   온도were refluxed overnight with a Dean-Stark
3. 3
   기타After evaporation of the solvent and separation on a silica gel column

실험 절차

The synthesis of starting materials (1)-(3) is known in the art. To prepare the next intermediate, (4), 9 g (44 mmol) of (3), 20 ml of ethylene glycol, 100 ml of benzene and 3 mg of p-toluene sulfonic acid were refluxed overnight with a Dean-Stark. After evaporation of the solvent and separation on a silica gel column, 9.2 g of the cetal (4) were obtained.

출처