반응 #41756

반응 방정식

4-fluoro-1-nitrobenzene

Ethyl piperazine

N,N-diisopropylethyl amine

→

4-Ethyl-1-(4-nitrophenyl)piperazine

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   농축Concentrated the resultant mixture
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   세척The organic layer was then washed with brine
4. 4
   건조dried with sodium sulfate
5. 5
   농축concentrated

실험 절차

To 4-fluoro-1-nitrobenzene (1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80° C. for 16 h. Concentrated the resultant mixture and partitioned between ethyl acetate and water. The organic layer was then washed with brine and dried with sodium sulfate and concentrated. Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235.

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