반응 #417424

반응 방정식

benzylamine

4,6-dimethyl-7-hydroxy-2-phenyl-1-indanone

→

4,6-dimethyl-7-hydroxy-1-benzylamino-2-phenyl-3H-indene

용매

dichloromethane

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타to obtain filtrate
3. 3
   세척The Celite used was washed with dichloromethane and ethanol
4. 4
   농축concentrated
5. 5
   기타Recrystallized from dichloromethane-ethanol

실험 절차

5.0 Grams of 4,6-dimethyl-7-hydroxy-2-phenyl-1-indanone was dissolved in 10 ml of diethyl ether and 10 ml of dichloromethane, then this solution was added dropwise gradually to a mixture of a solution of 2.55 ml of benzylamine in 10 ml of diethyl ether with 8 g of Molecular sieves 5A. The whole mixture was stirred at room temperature for 2 days and filtered by using Celite to obtain filtrate. The Celite used was washed with dichloromethane and ethanol, then these washing liquors were combined with the above-mentioned filtrate and concentrated. Recrystallized from dichloromethane-ethanol to obtain 3.83 g of 4,6-dimethyl-7-hydroxy-1-benzylamino-2-phenyl-3H-indene. Orange needle-like crystals. Melting point: 214°-215° C.

출처