반응 #417400

반응 방정식

hydrochloric acid

Methyl 3-(aminosulfonyl)-1-(2-pyridinyl)-1H-pyrazole-4-carboxylate

phenyl(4,6-dimethoxy-2-pyrimidinyl)carbamate

1,8-Diazabicyclo[5.4.0]undec-7-ene

→

title compound

Methyl [[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-1-(2-pyridinyl)-1H-pyrazole-4-carboxylate

용매

acetonitrile

—

ice water

반응 조건

후처리

1. 1
   기타The solid that separated
2. 2
   기타was collected

실험 절차

280 mg of Methyl 3-(aminosulfonyl)-1-(2-pyridinyl)-1H-pyrazole-4-carboxylate and phenyl(4,6-dimethoxy-2-pyrimidinyl)carbamate were dissolved in 10 mL of acetonitrile. 1,8-Diazabicyclo[5.4.0]undec-7-ene, 0.15 mL, was added, and the reaction was stirred one hour. The solution was diluted with 30 mL of ice-water and made acidic with concentrated hydrochloric acid. The solid that separated was collected to afford 260 mg of the title compound melting 183°-188° C.

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