반응 #41735

반응 방정식

2-[(4-bromophenyl)amino]benzoxazol-5-ol

potassium bis(trimethylsilyl)amide

4-chloro(2-pyridyl)-N-methylcarboxamide

Potassium carbonate

→

desired product

(4-{2-[(4-bromophenyl)amino]benzoxazol-5-yloxy}-(2-pyridyl))-N-methylcarboxamide

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타microwaved for 6 mins at 150° C
2. 2
   농축The reaction mixture was then concentrated
3. 3
   기타partitioned between ethyl acetate and water
4. 4
   기타The organic layer was separated
5. 5
   세척washed with brine
6. 6
   기타dried
7. 7
   여과filtered
8. 8
   농축concentrated
9. 9
   기타Purification on Prep LC

실험 절차

The mixture containing 2-[(4-bromophenyl)amino]benzoxazol-5-ol (1 eq), potassium bis(trimethylsilyl)amide (4 eq), was stirred in dimethylformamide for 30 min at room temperature. To this mixture was added (4-chloro(2-pyridyl)-N-methylcarboxamide (1 eq) and Potassium carbonate (1.2 eq) and microwaved for 6 mins at 150° C. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with brine, dried, filtered and concentrated. Purification on Prep LC yielded the desired product. MS: MH+=439.

출처