반응 #41733

반응 방정식

2-chloro-5-methoxybenzoxazole

4-bromoaniline

diisopropylethylamine

→

(4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine

용매

dimethylformamide

반응 조건

후처리

1. 1
   농축The resultant mixture was concentrated
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   세척The organic layer was washed with brine
4. 4
   기타dried
5. 5
   기타Purification on silica gel

실험 절차

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

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