반응 #41732

반응 방정식

5-methoxybenzoxazole-2-thiol

DMF

thionyl chloride

→

2-chloro-5-methoxybenzoxazole

반응 조건

후처리

1. 1
   농축The resultant mixture was concentrated
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   세척The organic layer was washed with brine
4. 4
   기타dried
5. 5
   농축concentrated
6. 6
   기타Purification on a silica gel column

실험 절차

The mixture containing 5-methoxybenzoxazole-2-thiol was heated in thionyl chloride with a drop of DMF. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated. Purification on a silica gel column gave 2-chloro-5-methoxybenzoxazole as a white solid. MS: MH+=184.

출처