반응 #416977

반응 방정식

morpholine

3-bromopropanol

→

3-morpholinopropanol

수율 98.6%

용매

diethyl ether

반응 조건

후처리

1. 1
   기타The reaction mixture was evaporated under vacuum and 300 ml of methylene chloride and 400 ml of a saturated aqueous solution of sodium bicarbonate
2. 2
   workup.ADDITIONwere added
3. 3
   workup.STIRRINGThe mixture was shaken
4. 4
   기타he organic layer was separated
5. 5
   세척washed twice with 300-ml portions of saturated aqueous sodium bicarbonate
6. 6
   기타The organic layer was separated
7. 7
   건조dried over sodium sulfate
8. 8
   기타evaporated

실험 절차

To a solution of 31.4 ml (360 mmol) of morpholine in 500 ml of diethyl ether were added slowly 10 g (71.94 mmole) of 3-bromopropanol and the mixture was stirred for one hour at room temperature. The reaction mixture was evaporated under vacuum and 300 ml of methylene chloride and 400 ml of a saturated aqueous solution of sodium bicarbonate were added. The mixture was shaken and he organic layer was separated and washed twice with 300-ml portions of saturated aqueous sodium bicarbonate. The organic layer was separated, dried over sodium sulfate and evaporated to yield 10.3 g of 3-morpholinopropanol.

출처