반응 #41696

반응 방정식

N-methoxy-N-methylamine hydrochloride

1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride

2-fluoro-4-nitrobenzoic acid

→

compound

2-fluoro-N-methoxy-N-methylbenzamide

용매

pyridine

반응 조건

후처리

1. 1
   기타the reaction liquid
2. 2
   기타Pyridine was evaporated away under reduced pressure, and water
3. 3
   workup.ADDITIONwas added to it
4. 4
   여과The resulting deposit was taken out through filtration
5. 5
   세척washed with water
6. 6
   기타dried

실험 절차

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

출처