반응 #41664

반응 방정식

nitric acid

N-(4-(3-((t-butyl(dimethyl)silyl)oxy)pyrrolidin-2-yl)-3-fluorophenyl)pyridine-2-carboxamide

→

1-acetyl-2-(2-fluoro-5-nitro-4-((pyridin-2-ylcarbonyl)amino)phenyl)pyrrolidin-3-yl acetate

반응 조건

후처리

1. 1
   기타the reaction liquid
2. 2
   기타The reaction liquid
3. 3
   workup.ADDITIONwas poured into a mixed solution of ice-aqueous saturated sodium bicarbonate
4. 4
   추출extracted with chloroform
5. 5
   건조dried with anhydrous sodium sulfate
6. 6
   기타The solvent was evaporated away under reduced pressure
7. 7
   기타the resulting residue was purified
8. 8
   기타through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=20/1)
9. 9
   기타to obtain diastereomer A and diastereomer B of the entitled compound each as a yellow oily substance

실험 절차

1 ml of fuming nitric acid was added to 57 mg of N-(4-(3-((t-butyl(dimethyl)silyl)oxy)pyrrolidin-2-yl)-3-fluorophenyl)pyridine-2-carboxamide, and the reaction liquid was stirred at room temperature for 40 minutes. The reaction liquid was poured into a mixed solution of ice-aqueous saturated sodium bicarbonate, extracted with chloroform, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=20/1) to obtain diastereomer A and diastereomer B of the entitled compound each as a yellow oily substance.

출처