반응 #41610

반응 방정식

6-methanesulfonyl-pyridin-3-ol

potassium carbonate

N-methylpyrrolidinone

2,3,4-trifluoro-nitrobenzene

→

2,3-difluoro-1-(6-methanesulfonyl-pyridin-3-yloxy)-4-nitro-benzene

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타the reaction liquid
2. 2
   기타The reaction liquid
3. 3
   세척washed with water and saturated saline in order
4. 4
   건조dried with anhydrous sodium sulfate
5. 5
   기타The solvent was evaporated away under reduced pressure
6. 6
   기타the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1)
7. 7
   기타to obtain the entitled compound

실험 절차

112 mg of 6-methanesulfonyl-pyridin-3-ol and 100 mg of potassium carbonate were added to an N-methylpyrrolidinone (3 ml) solution of 135 mg of 2,3,4-trifluoro-nitrobenzene, and the reaction liquid was stirred at 50° C. for 1 hour. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1) to obtain the entitled compound.

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