반응 #41570

반응 방정식

2-hydroxy-benzonitrile

potassium carbonate

N-methylpyrrolidinone

5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

→

5-(2-cyano-phenoxy)-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

용매

Water

반응 조건

후처리

1. 1
   기타obtained in (step 3)
2. 2
   기타the reaction liquid
3. 3
   여과the deposit was taken out through filtration
4. 4
   기타to obtain the entitled compound

실험 절차

60 mg of 2-hydroxy-benzonitrile and 70 mg of potassium carbonate were added to an N-methylpyrrolidinone (2 ml) solution of 150 mg of 5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine obtained in (step 3), and the reaction liquid was stirred at 90° C. for 5 hours. Water was added to the reaction liquid, and the deposit was taken out through filtration to obtain the entitled compound.

출처