반응 #415438

반응 방정식

2-(4-phenyl-4-hydroxypiperidinomethyl)-6-nitro-1-tetralone hydrochloride

hydrochloric acid

ammonium hydroxide

→

2-(4-phenyl-4-hydroxypiperidinomethyl)-6-amino-1-tetralone

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONA mixture of 4.17 g
2. 2
   온도the mixture is heated for 10 minutes more on a steam bath
3. 3
   온도to cool
4. 4
   추출extracted with chloroform

실험 절차

A mixture of 4.17 g. of 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-nitro-1-tetralone hydrochloride, 20 g. of iron-(II) sulfate heptahydrate, 45 ml. of water and 0.15 ml. of concentrated hydrochloric acid is heated at 100° with stirring. 10 ml. of concentrated ammonium hydroxide solution are added at 80° and the mixture is heated for 10 minutes more on a steam bath. It is allowed to cool, extracted with chloroform and worked up to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-amino-1-tetralone.

출처