반응 #41460

반응 방정식

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

수율 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

수율 98.0%

용매

Water

DMF

반응 조건

후처리

1. 1
   기타The beige-orange precipitate that formed
2. 2
   기타was collected by,
3. 3
   여과filtration
4. 4
   세척washed with water
5. 5
   기타dried in vacuo

실험 절차

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

출처