반응 #41456

반응 방정식

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

수율 98.1%

용매

Water

DMF

반응 조건

후처리

1. 1
   기타The light yellow precipitate that formed
2. 2
   여과was collected by filtration
3. 3
   세척washed with water
4. 4
   기타dried in vacuo

실험 절차

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

출처