반응 #414537
ord-f3b71019fdc74000bf0b9e63f0c756c0
반응 방정식
CO2
acetonedicarboxylic acid
glutaric dialdehyde
CH3NH2.HCl
sodium phosphate dibasic
NaOH
→
N-methyl-3-keto-9-azabicyclo[3.3.1]nonane
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
A 5-liter 3-necked flask was charged with 140 grams of 50% aqueous glutaric dialdehyde (Aldrich, 0.7 moles), 630 ml of water and 70.7 grams of CH3NH2.HCl (1.036 moles) which was first dissolved in 700 ml of water, 116.6 grams of acetonedicarboxylic acid (0.8 moles) which had been dissolved in 1162 ml of water, and a solution of 123.2 sodium phosphate dibasic and 10.22 grams of NaOH dissolved in 280 ml of water. The heterogeneous orange solution was stirred at room temperature for 24 hours during which time the evolution of CO2 (g) was noted.