반응 #414165

ord-90602cc878724a59a9a209d969e464c5

반응 방정식

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CC[C@@H]2O
19-Hydroxytestosterone
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2=O
19-hydroxyandrost-4-en-3,17-dione
[BH4-].[K+]
potassium borohydride
→
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2O
19-hydroxytestosterone
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2O
Androst-4-en-17,19-diol-3-one

반응물

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CC[C@@H]2O
19-Hydroxytestosterone
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2=O
19-hydroxyandrost-4-en-3,17-dione
[BH4-].[K+]
potassium borohydride

시약

없음

용매

CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타at -10° to 0° C
  2. 2
    추출Aqueous work up is followed by extraction and purification

실험 절차

Also known as 19-Hydroxytestosterone, this compound is commercially available from Steraloids, Inc. Alternatively, 19-hydroxyandrost-4-en-3,17-dione (11) is treated with potassium borohydride (KBH4, a) in ethanol at -10° to 0° C. Aqueous work up is followed by extraction and purification to yield 19-hydroxytestosterone (12).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05272134uspto-grants-1993_12