반응 #41415

반응 방정식

(αS,βR)-β{[1-(4-Pyridyl)-1H-indazole-5-yl]oxy}-α-methylbenzeneethanamine

Triethylamine

2-furoylchloride

→

title compound

수율 65.6%

N-[(1S,2R)-1-Methyl-2-phenyl-2-{[1-(4-pyridyl)-1H-indazole-5-yl]oxy}ethyl]furan-2-carboxamide

수율 65.6%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   건조dried over Na2SO4
3. 3
   여과The reaction mixture is filtered
4. 4
   기타the solvent evaporated
5. 5
   기타the residue purified by chromatography (silicagel, eluents: ethyl acetate/hexane)

실험 절차

(αS,βR)-β{[1-(4-Pyridyl)-1H-indazole-5-yl]oxy}-α-methylbenzeneethanamine (64.3 mg, 0.19 mmol) is dissolved in 7.1 mL of dichloromethane. Triethylamine (0.062 mL, 0.45 mmol) and 2-furoylchloride (24.3 mg, 0.19 mmol) are added. After 4 h stirring at r.t. the reaction mixture is diluted with dichloromethane, washed with water and brine and dried over Na2SO4. The reaction mixture is filtered, the solvent evaporated and the residue purified by chromatography (silicagel, eluents: ethyl acetate/hexane). 53.7 mg (65.6%) of the title compound are obtained.

출처