반응 #41398

반응 방정식

4-Chloro-2-fluoro-5-methoxy benzaldehyde

4-fluorophenylhydrazine

cesium carbonate

→

1-(4-Fluorophenyl)-6-chloro-5-methoxy-1H-indazole

용매

N-methylpyrrolidine

반응 조건

후처리

1. 1
   세척After dilution with DCM the mixture was washed with sat. NaHCO3, brine
2. 2
   기타the organic phase was evaporated
3. 3
   기타After purification of the crude by flash chromatography on silica gel 253 mg (84%) of the subtitle compound
4. 4
   기타were obtained

실험 절차

4-Chloro-2-fluoro-5-methoxy benzaldehyde (204 mg, 1.1 mmol) and 4-fluorophenylhydrazine (176 mg, 1.1 mmol) were dissolved in N-methylpyrrolidine (5 mL). After addition of cesium carbonate (1.15 g, 3.3 mmol) the mixture was heated in a microwave reactor (CEM Discovery, 150 Watt) to 150° C. for 20 min. After dilution with DCM the mixture was washed with sat. NaHCO3, brine and the organic phase was evaporated. After purification of the crude by flash chromatography on silica gel 253 mg (84%) of the subtitle compound were obtained.

출처