반응 #41379

반응 방정식

(1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine

triethyl amine

2-chloro-2-oxoethyl acetate

→

N-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-yl)-2-hydroxyacetamide

용매

THF

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.ADDITIONTo the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%)
3. 3
   workup.STIRRINGThe solution was stirred over night

실험 절차

To a stirred solution of (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine (91a, 13 mg, 0.03 mmol) in dry THF (1 ml) were added, at r.t., triethyl amine (28 μl, 0.2 mmol) and 2-chloro-2-oxoethyl acetate (10.8 μl, 0.1 mmol). The reaction was stirred over night. The solvent was removed under reduced pressure. To the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%). The solution was stirred over night.

출처