반응 #413588

반응 방정식

3-(2-Amino-4-thiazolyl)alanine

L-glutamic acid

Methanol

→

3-(2-amino-4-thiazolyl)-L-alanine L-glutamic acid salt

용매

water

반응 조건

후처리

1. 1
   기타to crystallize the salt
2. 2
   여과the product is filtered
3. 3
   세척washed with 40 L of methanol
4. 4
   기타The product is dried at 40° C. under vacuum

실험 절차

DL-3-(2-Amino-4-thiazolyl)alanine, 41.8 kg (223 mol) (Silberg, A., et al, Chemische Berichte, Vol. 97, pages 1767-69 (1964)) and 26.3 kg (179 mol) of L-glutamic acid are dissolved in 620 L of water at 60° C. Methanol (620 L) is added to the solution and the solution is cooled to 25° C. to crystallize the salt. After stirring for 2 to 3 hours at 25° C., the product is filtered and washed with 40 L of methanol. The product is dried at 40° C. under vacuum to give 37.6 kg of 3-(2-amino-4-thiazolyl)-L-alanine L-glutamic acid salt as a white solid. Infrared spectrum (IR) (mineral oil): 2927 (s, br), 1643 (s), 1605 (s), 1548 (s), 1407 (sh) cm-1.

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