반응 #41301

반응 방정식

(1R,2S)-2-amino-1-(naphthalen-2-yl)propan-1-ol hydrochloride

1-(4-fluorophenyl)-5-iodo-1H-indazole

Cesium carbonate

→

subtitle compound

(1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(naphthalen-2-yl)propan-2-amine hydrochloride

tert-butylmethylether HCl

용매

Butyronitrile

반응 조건

후처리

1. 1
   기타flushed with Argon
2. 2
   기타After final purification by HPLC the obtained material

실험 절차

The subtitle compound was prepared analogous to the method described in Example 19 (step 19a). (1R,2S)-2-amino-1-(naphthalen-2-yl)propan-1-ol hydrochloride (238 mg, 1.00 mmol), 1-(4-fluorophenyl)-5-iodo-1H-indazole (406 mg, 1.20 mmol), Cesium carbonate (979 mg, 3.00 mmol) and copper(I) iodide (38.1 mg, 0.20 mmol) in Butyronitrile (3 mL) was heated for 19 h at +125° C. in a sealed reactiontube flushed with Argon. After final purification by HPLC the obtained material was isolated as a brownish coloured hydrochloride salt from tert-butylmethylether/HCl.

출처