반응 #412526

반응 방정식

2-[4-(2,3-epoxypropoxy)phenyl]trifluoromethylimidazole

tert. butylamine

→

2-[4-(3-tert. butylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole

반응 조건

후처리

1. 1
   온도at reflux
2. 2
   기타The excess tert. butylamine is removed by distillation at atmospheric pressure over steam
3. 3
   기타The residue is triturated with nitromethane (5 ml.)
4. 4
   기타the resulting solid removed by filtration
5. 5
   기타After recrystallization from acetonitrile

실험 절차

A solution of 2-[4-(2,3-epoxypropoxy)phenyl]trifluoromethylimidazole (2.5 g.) in tert. butylamine (20 ml.) is heated 6 hours at reflux. The excess tert. butylamine is removed by distillation at atmospheric pressure over steam. The residue is triturated with nitromethane (5 ml.) and the resulting solid removed by filtration. After recrystallization from acetonitrile, (1.2 g.) of 2-[4-(3-tert. butylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole is obtained, m.p. 185.5°-186.5° C.

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