반응 #41233

반응 방정식

4,4′-dibromobiphenyl

cesium carbonate

product

Ethyl(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

→

title compound

Ethyl(3aR,6aR)-1-(4′-bromo-1,1′-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONThe catalyst solution was added to the vessel
2. 2
   여과filtered
3. 3
   기타to remove the catalyst
4. 4
   농축The resulting solution was concentrated under reduced pressure
5. 5
   기타the residue was purified by column chromatography

실험 절차

The catalyst solution was added to the vessel containing the 4,4′-dibromobiphenyl, cesium carbonate, and the product of Example 41C and the mixture was heated to 98° C. for 12 hours. The mixture was cooled to 20° C. and 80 g of dichloromethane was added. The resulting mixture was stirred and then filtered to remove the catalyst. The resulting solution was concentrated under reduced pressure and the residue was purified by column chromatography to yield 5.65 g of the title compound.

출처