반응 #412314

반응 방정식

dimethyl malonate

dec-9-en-1-ol

sodium methoxide

→

yellow oil

수율 59.7%

Malonic acid didec-9-enyl ester

수율 59.7%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas dropped in
2. 2
   기타formed
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   온도the mixture was cooled down
5. 5
   workup.ADDITIONdiluted with ether
6. 6
   세척washed with HCl 2N, saturated sodium bicarbonate and water
7. 7
   기타The organic phase was dried
8. 8
   여과filtered
9. 9
   기타evaporated to dryness
10. 10
    workup.DISTILLATIONThe resulting yellow oil was purified by distillation

실험 절차

To a mixture of 150 g dimethyl malonate and 464 g dec-9-en-1-ol, 30 g sodium methoxide (5.4 M in methanol) was dropped in. The mixture was heated to 120° C. to and the methanol formed was distilled off. After 6 hours, the mixture was cooled down, diluted with ether and washed with HCl 2N, saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by distillation to yield 258 g of a yellow oil.

출처