반응 #41201

반응 방정식

product

2-(4-Benzyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

EtOH

→

oil

수율 95.0%

2-(4-Hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

수율 95.0%

용매

THF

반응 조건

후처리

1. 1
   기타after flushing with hydrogen 3 times
2. 2
   여과The reaction mixture was then filtered
3. 3
   세척washed with THF (30 ml), EtOH (25 ml)
4. 4
   건조dried over anhydrous MgSO4
5. 5
   기타After removal of the solvent in vacuo

실험 절차

A solution of the product from step 1, in THF (11 ml), EtOH (25 ml), Pd—C (1.17 g, 10% wt) in a round bottom flask was charged with H2-balloon after flushing with hydrogen 3 times. The resulting solution was stirred overnight at rt. The reaction mixture was then filtered, washed with THF (30 ml), EtOH (25 ml) and dried over anhydrous MgSO4. After removal of the solvent in vacuo, the product was obtained as an orange oil (1.0 g, 95%).

출처