반응 #4112

반응 방정식

9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one

4-methylpiperidine

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product

수율 83.0%

9-Bromo-6-(4-methyl-1-piperidinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

수율 83.0%

용매

toluene

반응 조건

후처리

1. 1
   온도was heated under nitrogen
2. 2
   기타resulted
3. 3
   온도The mixture was refluxed for 3 hours
4. 4
   여과filtered
5. 5
   workup.STIRRINGThe filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes
6. 6
   기타the layers were separated
7. 7
   추출The aqueous phase was extracted with 250 ml of toluene
8. 8
   세척washed once with 2N sodium hydroxide solution, twice with water
9. 9
   건조dried over anhydrous sodium sulfate
10. 10
    여과filtered
11. 11
    농축concentrated in vacuo to an oil which
12. 12
    기타The solid was triturated twice with hexane

실험 절차

A mixture of 4.73 g (0.0150 mole) of 9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one and 1000 ml of toluene was heated under nitrogen, with stirring, until a solution resulted. Then there was added 14.9 g (0.150 mole) of 4-methylpiperidine, followed by 8.54 g (0.045 mole) of titanium tetrachloride. The mixture was refluxed for 3 hours, cooled to room temperature and filtered. The filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes and the layers were separated. The aqueous phase was extracted with 250 ml of toluene. The toluene layers were combined, washed once with 2N sodium hydroxide solution, twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to an oil which solidified. The solid was triturated twice with hexane to afford 4.9 g (83%) of product. Recrystallization from ethyl acetate provided the analytical sample, mp 177°-179° C.

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