반응 #41117

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5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

triethylamine

1,2,4-triazole

→

Methyl-5-[1,2,4]triazol-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

반응 조건

후처리

1. 1
   온도Heating
2. 2
   기타under microwave irradiation for 4 hr
3. 3
   기타provided
4. 4
   기타after purification by reverse phase HPLC, 1-methyl-5-[1,2,4]triazol-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (11 mg, 11%) as an off-white powder

실험 절차

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol), triethylamine (0.22 mL; 1.56 mmol) and 1,2,4-triazole (0.21 g; 3.0 mmol) under microwave irradiation for 4 hr according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 1-methyl-5-[1,2,4]triazol-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (11 mg, 11%) as an off-white powder. ES-HRMS m/e calcd for C17H22N6O (M+H+) 327.1928, found 327.1924.

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