반응 #410861

반응 방정식

2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenol

ethyl 3-bromobutyrate

potassium carbonate

N,N-dimethylformamide

→

ethyl 2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenoxybutyrate

수율 90.0%

용매

water

반응 조건

후처리

1. 1
   추출extracted twice with 50 ml of diethyl ether
2. 2
   세척washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated
5. 5
   기타to give a crude product

실험 절차

A reaction vessel was charged with 2.02 g of 2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenol, 1.56 g of ethyl 3-bromobutyrate, 1.11 g of potassium carbonate and 20 ml of N,N-dimethylformamide. After stirring at room temperature for 12 hours, the reaction mixture was poured into water and extracted twice with 50 ml of diethyl ether. The ether layers were combined, washed with water, dried over anhydrous magnesium sulfate, and then concentrated to give a crude product. The crude product was subjected to silica gel chromatography, which afforded 2.54 g of ethyl 2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenoxybutyrate (90% yield).

출처