반응 #410583

반응 방정식

methyl 3-methoxy-4,5-ethylenedioxybenzoate

lithium hydroxide

→

title compound

3-Methoxy-4,5-ethylenedioxybenzoic acid

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도Heat to reflux
2. 2
   온도cool
3. 3
   기타the reaction
4. 4
   농축concentrate in vacuo
5. 5
   기타to remove most of the tetrahydrofuran
6. 6
   온도Cool in a ice bath
7. 7
   기타to give a solid
8. 8
   기타Collect the solid
9. 9
   여과by filtration
10. 10
    기타dry

실험 절차

Combine methyl 3-methoxy-4,5-ethylenedioxybenzoate (0.46 g, 2.0 mmol) and tetrahydrofuran (15 mL). Add a 1 M aqueous solution of lithium hydroxide (2.5 mL, 2.5 mmol). Heat to reflux. After 15 hours, cool the reaction, concentrate in vacuo to remove most of the tetrahydrofuran. Cool in a ice bath and acidify with a 1 M aqueous hydrochloric acid solution to give a solid. Collect the solid by filtration and dry to give the title compound.

출처