반응 #410266
ord-8c14a2bdaec942578f78556c6c0bb185
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with water
- 2건조The organic layer was dried over MgSO4
- 3여과filtered
- 4기타The solvent was evaporated
실험 절차
2-trifluoromethyphenol (3.00 g, 18.5 mmol) was dissolved in methylene chloride(40 mL) followed by the addition of sodium nitrate (1.73 g, 20.4 mmol). The addition of sulfuric acid (23 mL/3M) was then made, followed by addition of a catalytic amount of sodium nitrite. The mixture was allowed to stir. After 24 hours, the reaction mixture was diluted with methylene chloride and extracted with water. The organic layer was dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4% MeOH/CH2Cl2) gave the desired product(1.84 g, 47%). 1H NMR (CD3COCD3): d 8.35 (d, 1H), 7.95 (d, 1H), 7.13 (t, 1H).