반응 #410058

반응 방정식

3-benzyloxyphenol

ethyl (RS)-4-chloro-4-phenylbutanoate

potassium carbonate

potassium iodide

→

ethyl (RS)-4-(3-benzyloxyphenoxy)-4-phenylbutanoate

수율 17.1%

용매

methyl ethyl ketone

반응 조건

후처리

1. 1
   온도is heated
2. 2
   온도at reflux for 40 hours
3. 3
   기타The mixture is evaporated to dryness
4. 4
   기타the residue is partitioned between ethyl acetate (200 mL) and water (200 mL)
5. 5
   건조The organic layer is dried over magnesium sulphate
6. 6
   여과filtered
7. 7
   농축concentrated in vacuo
8. 8
   세척Flash chromatography of the resulting oil, eluting with a mixture of ethyl acetate and cyclohexane (1:19 v/v)

실험 절차

A mixture of 3-benzyloxyphenol (3 g), ethyl (RS)-4-chloro-4-phenylbutanoate (4.53 g), potassium carbonate (4.14 g), potassium iodide (100 mg) and methyl ethyl ketone (100 mL) is heated at reflux for 40 hours. The mixture is evaporated to dryness and the residue is partitioned between ethyl acetate (200 mL) and water (200 mL). The organic layer is dried over magnesium sulphate, filtered, and concentrated in vacuo. Flash chromatography of the resulting oil, eluting with a mixture of ethyl acetate and cyclohexane (1:19 v/v), gives ethyl (RS)-4-(3-benzyloxyphenoxy)-4-phenylbutanoate (1 g), in the form of a yellow oil.

출처