반응 #40992

반응 방정식

2,4-Dimethoxy-pyrimidine-5-boronic acid

2-chloro-5-iodopyridine

Na2CO3

PPh3

→

title compound

5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

용매

n-PrOH

반응 조건

후처리

1. 1
   온도at reflux for 2.5 hours
2. 2
   기타The solvent was evaporated under vacuum
3. 3
   기타the crude was partitioned between water and DCM
4. 4
   건조The organic phase was dried (Na2SO4)
5. 5
   기타evaporated

실험 절차

2,4-Dimethoxy-pyrimidine-5-boronic acid (1.14 g, 6.26 mmol) was dissolved in degassed n-PrOH (20 ml) and then 2-chloro-5-iodopyridine (1 g, 4.2 mmol), Na2CO3 (884 mg, 15.8 mmol), PPh3 (109 mg, 0.42 mmol) and Pd(OAc)2 (46 mg) were added. The suspension was stirred at reflux for 2.5 hours. The solvent was evaporated under vacuum and the crude was partitioned between water and DCM. The organic phase was dried (Na2SO4) and evaporated to give the title compound that was used in the next step without further purification (quantitative yield).

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