반응 #40968

반응 방정식

2,4-Dimethoxy-pyrimidine-5-boronic acid

5-iodo-2,4-dimethyl-oxazole

Na2CO3

PPh3

→

title compound

수율 67.1%

5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine

수율 67.1%

용매

n-PrOH

반응 조건

후처리

1. 1
   온도at reflux for 4 hours
2. 2
   기타The solvent was evaporated under vacuum
3. 3
   기타the crude was partitioned between water and ethyl acetate
4. 4
   건조The organic phase was dried (Na2SO4)
5. 5
   기타evaporated
6. 6
   기타The crude was purified by SCX cartridge

실험 절차

2,4-Dimethoxy-pyrimidine-5-boronic acid (840 mg, 4.6 mmol) was dissolved in degassed n-PrOH (40 mL) and then 5-iodo-2,4-dimethyl-oxazole (Prep60, 850 mg, 3.8 mmol), Na2CO3 (848 mg, 8 mmol), PPh3 (332 mg, 1.3 mmol) and Pd(OAc)2 (85 mg, 0.38 mmol) were added. The suspension was stirred at reflux for 4 hours. The solvent was evaporated under vacuum and the crude was partitioned between water and ethyl acetate. The organic phase was dried (Na2SO4) and evaporated. The crude was purified by SCX cartridge to give 600 mg of the title compound (66% yield).

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