반응 #409667

반응 방정식

MeOH CHCl3

1-naphthalenemethylisothiocyanate

4-aminomethylpiperidine

→

desired product

수율 54.0%

1-Naphthalene-1-ylmethyl-3-piperidine-4-ylmethylthiourea

수율 54.0%

용매

MeOH THF

반응 조건

후처리

1. 1
   온도at reflux for 12 h
2. 2
   농축The reaction mixture was concentrated in vacuo
3. 3
   기타yielding oily mixture which

실험 절차

To a solution of 1-naphthalenemethylisothiocyanate (2.8 g, 13.6 mmol) in 100 ml of MeOH-THF solution (1:1 mixture) was added 4-aminomethylpiperidine (3.1 ml, 27.0 mmol) in a portion and the resulting solution was stirred at reflux for 12 h. The reaction mixture was concentrated in vacuo, yielding oily mixture which was subjected to column chromatography (10% MeOH/CHCl3) to yield 2.3 g (48%) of the desired product as an oil.

출처