반응 #409590

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1-[4-(4-hydroxyphenyl)butyl]imidazole

4-chloromethyl-2-phenyloxazole

→

4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole

수율 89.0%

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실험 절차

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenyloxazole. The yield was 89%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 113-114° C.

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