반응 #409589

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1-[4-(3-hydroxyphenyl)butyl]imidazole

2-(4-benzyloxyphenyl)-4-chloromethyloxazole

→

2-(4-benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole

수율 78.0%

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실험 절차

In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 87-88° C.

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