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4-[4-[3-(1-imidazolyl)propyl]-phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole

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4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-phenylethyl)oxazole

수율 57.0%

용매

ethanol

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후처리

1. 1
   기타was subjected to catalytic hydrogenation at room temperature under atmospheric pressure
2. 2
   여과The catalyst was filtered off
3. 3
   농축The filtrate was concentrated
4. 4
   기타to leave a crystalline product, which
5. 5
   기타was recrystallized from ethyl acetate-hexane

실험 절차

To a solution of 4-[4-[3-(1-imidazolyl)propyl]-phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole (300 mg) in ethanol (100 ml) was added palladium-carbon (5%, wet, 300 mg). The mixture was subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The catalyst was filtered off. The filtrate was concentrated to leave a crystalline product, which was recrystallized from ethyl acetate-hexane to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-phenylethyl)oxazole (170 mg, 57%) as colorless prisms, mp 67-68° C.

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