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1-[3-(4-hydroxyphenyl)propyl]imidazole

4-chloromethyl-2-(4-cyanophenyl) oxazole

→

2-(4-cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

수율 72.0%

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실험 절차

In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(4-cyanophenyl) oxazole to give 2-(4-cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 72%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 98-99° C.

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