반응 #40954

반응 방정식

water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

1-bromo-4-chloro-butane

→

title compound

수율 98.0%

3-Benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

수율 98.0%

용매

DMF

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   건조The organic phase was dried (Na2SO4)
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   기타the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3)

실험 절차

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 2.5 g, 7.3 mmol), K2CO3 (1 g, 7.3 mmol) and 1-bromo-4-chloro-butane (2.10 mL, 18 mmol) were suspended in dry DMF (10 mL). After stirring the reaction at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated; the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3) to give the title compound as a white solid (3 g, 98% yield).

출처