반응 #409495

반응 방정식

1-[4-(4-benzyloxyphenyl)butyl]imidazole

→

1-[4-(4-hydroxyphenyl)butyl]imidazole

수율 94.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타was subjected to catalitic hydrogenation at room temperature under 1 atom
2. 2
   여과The catalyst was filtered off
3. 3
   농축the filtrate was concentrated

실험 절차

A mixture of 1-[4-(4-benzyloxyphenyl)butyl]imidazole (13.0 g), palladium-carbon (5%, 10.0 g) and ethanol (100 ml) was subjected to catalitic hydrogenation at room temperature under 1 atom. The catalyst was filtered off, and the filtrate was concentrated to give 1-[4-(4-hydroxyphenyl)butyl]imidazole (8.58 g, 94%). Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 124-125° C.

출처