반응 #409438

반응 방정식

1-[4-(4-benzyloxyphenyl)butyl]-1,2,4-triazole

→

1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole

수율 55.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타was subjected to catalytic hydrogenation under atmospheric pressure at room temperature
2. 2
   여과The catalyst was filtered off
3. 3
   농축the filtrate was concentrated
4. 4
   기타The crystalline product obtained from the fraction
5. 5
   세척eluted with tetrahydrofuran-hexane (1:1
6. 6
   기타v/v) was recrystallized from ethyl acetate-hexane

실험 절차

A mixture of 1-[4-(4-benzyloxyphenyl)butyl]-1,2,4-triazole (3.15 g), palladium-carbon (5%, 3.0 g) and ethanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated. The residue was subjected to a silica gel column chromatography. The crystalline product obtained from the fraction eluted with tetrahydrofuran-hexane (1:1, v/v) was recrystallized from ethyl acetate-hexane to give 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole (1.22 g, 55%) as colorless prisms, mp 135-136° C.

출처