반응 #409232

반응 방정식

Acetyl chloride

D-phenylglycine

→

title compound

D-Phenylglycine methyl ester hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONWhen the addition
2. 2
   workup.DISSOLUTIONuntil dissolved
3. 3
   기타The solvent was evaporated

실험 절차

Acetyl chloride (4 ml) was added cautiously and dropwise to methanol (20 ml) at 0° C. over 2 minutes. When the addition was completed, D-phenylglycine (1 g, 5.9 mmol, Aldrich) was introduced in a single portion. The mixture was stirred until dissolved then allowed to stand at RT for 24 hours. The solvent was evaporated then coevaporated twice from toluene to afford the title compound as a white crystalline solid in quantitative yield. The title compound was obtained as a white crystalline solid in quantitative yield with an identical n.m.r. spectrum to the L-isomer.

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